Cytochrome c oxidase activity
Contributor: Giampaolo Morciano
{"name":"Cytochrome c oxidase 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Theorem
Information
The last complex of the electron transport chain (CIV, also termed cytochrome c oxidase) is located at the inner mitochondrial membrane (IMM), especially at cristae compartment, catalyzing the reduction of oxygen to water. In this process, CiV translocates four H+ across the IMM increasing the transmembrane difference of proton electrochemical potential, used to synthesize ATP.
References:
Zong S, Wu M, Gu J, Liu T, Guo R, Yang M. Structure of the intact 14-subunit human cytochrome c oxidase. Cell Res. 2018 Oct;28(10):1026-1034. doi: 10.1038/s41422-018-0071-1. Epub 2018 Jul 20. PMID: 30030519.
Soto IC, Fontanesi F, Liu J, Barrientos A. Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core. Biochim Biophys Acta. 2012
Jun;1817(6):883-97. doi: 10.1016/j.bbabio.2011.09.005. Epub 2011 Sep 16. PMID: 21958598.
Sinkler CA, Kalpage H, Shay J, Lee I, Malek MH, Grossman LI, Hüttemann M. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease. Oxid Med Cell Longev. 2017;2017:1534056. doi: 10.1155/2017/1534056. Epub 2017 May 16. PMID: 28593021.
Link to other Databases:
KEGG: https://www.genome.jp/dbget-bin/www_bget?pathway:map00190
Mitochondrial processes
Demonstrative and biological steps
Dynamic view
Mito-location
Not Available/Not Relevant
Matrix
Inner Membrane
Inter-Membrane Space
Outer Membrane
